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No, sadly there is no AMEX lounge at MDW but there is a Priority Pass lounge coming to Midway in Fall of 2024 called The Club MDW!
It’s no AMEX Centurion lounge but it is better than nothing, especially if you fly Southwest or live on the south side of Chicago.
thepointsguy.com
Chicago's Midway Airport to get its 1st lounge next year - The Points Guy
Chicago's Midway International Airport will land its first lounge in 2024. It will be part of the Priority Pass network.